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Oxybutynin transdermal generic tablets USP, for oral ingestion, containing: Phenoxybutynin 100 mg pH 3.9 pregnant or lactating women No information about interactions Contraindications Contraindications Use with caution in patients known to be susceptible seizures. Interactions None well documented. Adverse Reactions Fatal and nonfatal cases may be associated with severe hypotension and respiratory suppression. Nonteratogenic effects have resulted from administration, particularly when parenteral or oral treatment is used together with the metabolic acidosis of renal failure. Precautions General Carcinogenesis, Mutagenesis, Impairment of Fertility No human data from in vitro or animal studies were identified, but is also not known whether phenoxybutynin or methylxanthines were mutagenic in vitro or to cause mutations in a human cell line vivo. The use of phenoxybutynin in pregnancy has not been studied in humans and no pregnancies have been reported. teratogenic effects reported in humans. Pregnancy Category D, Caution Numerous reports of developmental and congenital anomalies the female fetus have been obtained after prenatal administration of phenoxybutynin generic oxybutynin cost (see Warnings and Precautions—Pregnancy). It is not known whether phenoxybutynin teratogenic in humans or animal. Therefore, pregnant women should not take phenoxybutynin tablets. Teratogenic Effects Prenatal administration of phenoxybutynin (up to 10 mg/day) rats has generated fetal harm when given up to 17 weeks of age after oral administration. It has been concluded that phenoxybutynin (as its metabolite, 3,4-methylenedioxy-Phenoxyacetic acid [MAPP]) (see Cautions) is not teratogenic. No evidence exists that phenoxybutynin is a teratogen in women. However, in clinical trials, a high incidence of fetal harm to the fetus (i.e., 5%–20%) was observed in the phenoxybutynin-treated rats. Studies of effect treatment with phenoxybutynin on the placenta have not been performed. Adverse Reactions Common Adverse Reactions Associated with Phenoxybutynin Adverse reactions are more common with parenteral and oral administration of phenoxybutynin. Cardiovascular and respiratory effects Frequent or sudden cardiac rhythm disturbances death have been reported in clinical trials with phenoxybutynin. A high incidence of cardiac toxicity, especially as online pharmacy oxycodone 30mg observed with doses up to 2,500 mg/d (see section 6.4), was observed in rats. In animal studies on rats weighing 200–700 g, a dose of 150 mg/kg/day phenoxybutynin caused cardiomyopathy, congestive heart failure, pulmonary edema, and death within one day [see DOSAGE AND ADMINISTRATION]. In human studies patients at the recommended dose for phenoxybutynin, incidence of arrhythmias was about 5%; the incidence 0.05% with doses Montelukast buy uk of 500 mg or greater and 0.1% with doses of 250–500 mg/day.

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