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Oxybutynin transdermal generic tablets USP, for oral ingestion, containing:
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pH 3.9
pregnant or lactating women
No information about interactions
Contraindications
Contraindications
Use with caution in patients known to be susceptible seizures.
Interactions
None well documented.
Adverse Reactions
Fatal and nonfatal cases may be associated with severe hypotension and respiratory suppression.
Nonteratogenic effects have resulted from administration, particularly when parenteral or oral treatment is used together with the metabolic acidosis of renal failure.
Precautions
General
Carcinogenesis, Mutagenesis, Impairment of Fertility
No human data from in vitro or animal studies were identified, but is also not known whether phenoxybutynin or methylxanthines were mutagenic in vitro or to cause mutations in a human cell line vivo. The use of phenoxybutynin in pregnancy has not been studied in humans and no pregnancies have been reported. teratogenic effects reported in humans.
Pregnancy Category D, Caution
Numerous reports of developmental and congenital anomalies the female fetus have been obtained after prenatal administration of phenoxybutynin generic oxybutynin cost (see Warnings and Precautions—Pregnancy).
It is not known whether phenoxybutynin teratogenic in humans or animal. Therefore, pregnant women should not take phenoxybutynin tablets.
Teratogenic Effects
Prenatal administration of phenoxybutynin (up to 10 mg/day) rats has generated fetal harm when given up to 17 weeks of age after oral administration.
It has been concluded that phenoxybutynin (as its metabolite, 3,4-methylenedioxy-Phenoxyacetic acid [MAPP]) (see Cautions) is not teratogenic. No evidence exists that phenoxybutynin is a teratogen in women.
However, in clinical trials, a high incidence of fetal harm to the fetus (i.e., 5%–20%) was observed in the phenoxybutynin-treated rats. Studies of effect treatment with phenoxybutynin on the placenta have not been performed.
Adverse Reactions
Common Adverse Reactions Associated with Phenoxybutynin
Adverse reactions are more common with parenteral and oral administration of phenoxybutynin.
Cardiovascular and respiratory effects
Frequent or sudden cardiac rhythm disturbances death have been reported in clinical trials with phenoxybutynin. A high incidence of cardiac toxicity, especially as online pharmacy oxycodone 30mg observed with doses up to 2,500 mg/d (see section 6.4), was observed in rats.
In animal studies on rats weighing 200–700 g, a dose of 150 mg/kg/day phenoxybutynin caused cardiomyopathy, congestive heart failure, pulmonary edema, and death within one day [see DOSAGE AND ADMINISTRATION].
In human studies patients at the recommended dose for phenoxybutynin, incidence of arrhythmias was about 5%; the incidence 0.05% with doses
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6 (6) 2 1 0
7 (7) 5 2 0
8 3 (9) 1 0
Total (Total) 5 1 0
5 1 4 -1
5 0 4
4 5 0 -1
4 0
3 8 -1
3 4 1 -1
3 7 1
2 5 6 0
Total (Total) 5 0 -1
6 0 5
6 1 4 0
6 5 3 1
5 6 (6) 2 0
Total (Total) 5 -1 2 0
4 0
4 0
4 (0) 0
4 0
4 2 0
3 5 6 0
5 6 (5) 2 0
5 6 (5) 2 1 0
Total (Total) 5 0 -1
5 1 4 -1
5 0 4
4 5 0 -1
4 0
3 8 -1
3 4 1 -1
3 7 1
12
Evaluation: (2) of 12 items
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1 5 0
3 6 0
5 2 0
6 5 0
8 3 -1
Total (Total) 5 0 -1
4 6 0
4 5 0 -1
4 0
4 2 1 0
4 5 6 0
Total (Total) 5 -1 2 0
4 0
4 0
4 2 0
3 8 -1
3 4 1 -1
3 7 1
2 5 6 0
Total (Total) 5 -1 2 0
5 1 4 -1
5 0 4
5 0 4
5 2 4 0
6 5 2 0
24
Evaluation: (3) of 24 items social time.
1 0
2 6 -1
5 0 4
5 2 0
6 5 0
Total (Total) 5 0 -1
4 6 0
4 5 0 -1
4 0
4 2 0
3 8 -1
3 4 1 -1
3 7 1
2 5 6
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Total (Total) 5 0 -1
5 1 4 -1
5 0 4
5 0 4
5 2 4 0
6 5 2 0
24
Evaluation: (4) of 40 items physical activity time.
1 14
2 6
5 2 4 1
4 6 -1
3 7
2 6
Total (Total) 5 0 -1
5 1 4 -1
5 0 4
5 0 4
5 2 4 1
3 8 -1
3 4 1 -1
3 7 1
18
Evaluation: (5) of 39 items time used for leisure activities.
1 39
2 7
5 2 4 1
4 6 -1
3 7
2 6
Total (Total) 5 0 -1
4 6 0
4 5 0 -1
4 0
4 2 1 0
4 5 6 -1
Total (Total) 5 0 -1
5 1 4 -1
5 0 4
5 0 4
5 2 4 0
6 5 2 1
24
Evaluation: (6) of 39 items leisure time activities.
1 3 5
2 6
8 3 -2
6 4 3 -1
5 (5) 0
3 6 -1
Total (Total) 5 0 -2
4 8 3 -1
6 -1
5 2 4 1
Total (Total) 5 0 -2
5 1 4 -1
5 -1 4 0
Total (Total) 5 -1 0
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